3M™ Harvest RC
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Details
Highlights
- Single-stage, single-use chromatographic clarification solution
- Replaces primary, secondary, and guard membrane clarification stages
- Remove cells, cell debris and DNA (<500 ppb) from the harvested cell culture fluid
- High mAb product recovery (90-95%)
- Predictably scales from laboratory to manufacturing
3M™ Harvest RC is the next generation in harvest and clarification technology for high cell density cultures. This solution is designed as an efficient option to increase monoclonal antibody (mAb) yields while simplifying the upstream process by replacing the centrifuge and/or depth filtration unit operations.
Suggested applications
- Clarification for CHO harvest cell culture fluid
- Significant turbidity reduction
- Single-stage chromatographic clarification
Specifications
| Applications | Optimized Harvest and Clarification Device, DNA Removal, Single Stage Clarification, Turbidity Reduction, Biopharmaceutical Manufacturing, HCP, Bioprocessing, mAb Production |
| Autoclavable | Yes |
| Brands | 3M™ |
| Capsule Material | Polypropylene, Polysulfone, Glass Filled Polypropylene, Thermoplastic Elastomer (TPE), Fluorocarbon, Polycarbonate, Silicone |
| Effective Filtration Area (metric) | 0.23 cm², 1.61 cm², 2.3 m², 3.2 cm², 25 cm², 340 cm², 1020 m² |
| End Modification | 3/4" Sanitary, 1-1/2" Sanitary, Luer-Lok |
| Factory Integrity Tested | Capsule Leak Test |
| Fill Volume | 0.66 mL, 1.7 L, 3.3 L, 5.6 mL, 15 mL, 16.3 L, 27.6 L, 28.2 mL |
| Flow Rate (metric) | 0.53 Millilitre per Minute, 2.7 Millilitre per Minute, 4.2 Millilitre per Minute, 57 Millilitre per Minute, 170 Millilitre per Minute, 380 Litre per minute |
| Gamma Compatible | No |
| Gamma Sterilized | No |
| Gasket/O-ring Material | Fluorocarbon, Silicone |
| Industries | Life Sciences |
| Inlet Outlet Size | 1.5", 3/4" |
| Inlet/Outlet Connections | 3/4 in Sanitary Connectors, 1 1/2 in Sanitary Connectors, Luer Loc |
| Maximum Operating Pressure (Metric) | 2.8 bar, 3.1 bar, 3.4 bar |
| Maximum Operating Temperature (Celsius) | 40 ℃ |
| Media Material | Functional Non-woven |
| Media Technology | Anion exchange chromatography |
| Media Type | Single Use |
| Membrane Micron Rating | 0.2 μm |
| Membrane Type | PES |
| Net Weight (Metric) | 1.1 g, 1.6 kg, 3.4 kg, 9.8 g, 14.3 kg, 69.2 kg, 75.8 g |
| Product Series | Harvest RC |
| Saleable Unit | EA |
| Shelf Life | 2 Year |
| Storage Temperature (Celsius) | 0 °C - 30 °C |
| Temperature Range (Celsius) | 0 °C - 40 °C |
| Units per Case | 1.0, 2.0, 4.0, 12.0 |
| Overall Diameter (Metric) | 2.9 cm, 4.3 cm, 7.7 cm, 24.1 cm, 45.2 cm |
| Overall Height (Metric) | 5.3 cm, 5.7 cm, 5.9 cm, 6.1 cm, 8.6 cm, 8.9 cm, 10.4 cm, 15.2 cm, 20.3 cm |
| Overall Length (Metric) | 12.7 cm |
| Overall Width (Metric) | 8.6 cm |
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